Project:

Gene expression and physiological effects of carcinogens of tardigrades

Students:

Hampton Gaddy, Alekya kaeveti

Institution:

Icahn School of Medicine at Mount Sinai, Manhattan

Mentors:

Matthew O'connell

Abstract:

This project investigates the effects of carcinogens on gene expression in the Tardigrade Hypsibius dujardini. This organism is characterized by extreme resistance to radiation and other cellular stresses. Using genome sequence data, we have surveyed the expression of genes that represent all major DNA repair pathways. The data show a general down-regulation of gene expression, which may represent a physiological response of a general toxicity of the carcinogens.

Poster:

Team samples: